![]() ![]() ĭiagnosis of cognitively intact, amnestic MCI, or AD in ADNI is based on a cognitive screening battery that includes the Mini-Mental State Examination (MMSE), immediate and delayed recall of the first Logical Memory story (Anna Thompson) from the Wechsler Memory Scale-Revised, and the Clinical Dementia Rating (CDR) interview conducted with each subject and their program partner. Additional inclusion/exclusion criteria are available at. Inclusion criteria for ADNI require an age range between 55 and 90 years, a minimum of 6 years of formal education, fluency in English or Spanish, Hachinski Ischemic Scale scores ≤4 points (out of a possible 18), and Geriatric Depression Scale Short Form scores 2 doses per week). The primary goal of ADNI has been to test whether serial magnetic resonance imaging, positron emission tomography, other biological markers, and clinical and neuropsychological assessment can be combined to measure the progression of MCI and early AD. The ADNI was launched in 2003 as a public-private partnership, led by the principal investigator Michael W. ![]() reported that with the exception of the Language Index Score (AUC = 0.58), the AUCs of the other index scores (range = 0.61–0.63) were also significant predictors of conversion from MCI to AD.ĭata used in the preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database ( ). While not as strong as the Memory Index (area under the curve = 0.66) in predicting conver sion to AD, Julaynont et al. Conversion to AD was 90.5% in patients with scores below the cutoff for impairment on both the total score (< 20/30 points) and the Memory Index Score (< 7/15 points), 74.5% when 1 score was below the cutoff, and 53% when both scores were above the cutoff. The investigators found that both the traditional total score and the Memory Index Score, consisting of the performance on delayed free, cued, and recognition conditions of the word list, were strong predictors of conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD) over an average follow-up of 18 months. developed MoCA index scores for the domains of memory, executive function, visuospatial function, language, attention, and orientation. Traditional interpretation of the MoCA is based upon the summed points across all items, with a maximum of 30 points. The Montreal Cognitive Assessment (MoCA) is a popular test used for cognitive screening in dementia clinics. A combined score has stronger incremental validity than the individual index scores. Conclusion: Administration of the entire MoCA is more informative than the index scores, especially in distinguishing normal cognition versus MCI. A combined score incorporating the Memory, Executive, and Orientation indexes also improved incremental validity for all 3 group comparisons. Results: Effect sizes for the total score were large (> 0.80) and exceeded the index scores in differentiating those with MCI versus normal cognition, MCI versus AD, and AD versus normal cognition. Methods: Effect sizes were calculated for Alzheimer’s Disease Neuroimaging Initiative research participants with normal cognition ( n = 295), MCI ( n = 471), or AD ( n = 150). Educational level had a significant impact on MoCA scores.Background/Aims: The aim of this paper was to evaluate the incremental validity of the Montreal Cognitive Assessment (MoCA) index scores and the MoCA total score in differentiating individuals with normal cognition versus mild cognitive impairment (MCI) or Alzheimer disease (AD). Conclusions: Approximately 50% scored below the cut-off score of 26 points, suggesting that the cut-off score may have been set too high to distinguish normal cognitive function from MCI. Those with higher education had significantly higher scores (mean 26.2, 95% CI 26.1–26.3 vs. The mean MoCA score was 25.3 (95% confidence interval 25.2–25.4), and 49% had a score below the suggested cut-off of 26 points. Results: MoCA scores were available in 3,413 participants, of which 47% had higher education (>12 years). The participants were aged 63–65 at the time of data collection. Methods: MoCA scores were assessed in the Akershus Cardiac Examination 1950 Study, a cross-sectional cohort study of all men and women born in 1950 living in Akershus County, Norway. AbstractAims: To investigate Montreal Cognitive Assessment (MoCA) test scores in a cohort aged 63–65 years from a general population in relation to the proposed cut-off score of 26 for mild cognitive impairment (MCI) and to explore the impact of education. ![]()
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